If you are playing Insanity difficulty in Resident Evil Requiem, you will quickly notice that the game removes many hints that normally help you solve puzzles. In this guide, you will find all safe codes for Insanity difficulty in Resident Evil Requiem so you can open every locked safe without searching the entire area.
Examination Room Insanity Safe Code
- Left 50 > Right 30 > Left 90
This safe is located inside the Examination Room in the East Wing of the Care Center. It rewards you with three Antique Coins. You can use these coins in the Parlor to unlock different upgrades.
Bar & Lounge Insanity Code
- Left 70 > Right 50 > Left 20
This safe is located behind the counter in the Care Center Bar & Lounge area. Opening it will reward you with three Antique Coins.
Basement Insanity Safe Code
- Left 70 → Right 50 → Left 20
You can find this safe in the Care Center Basement, near the Furnace/Inspection area, after you progress further in the story. It rewards you with Handgun Ammo and the Raccoon Roundup Map.
Sterilization chamber Safe Code
- Left 80 → Right 50 → Left 0
This safe is located in the ARK facility inside the Sterilization Chamber. The rewards include a Med Injector, Molotov Cocktail, and Handgun Ammo.
Monitor Control Room Insanity Safe Code
- Right 20 → Left 0 → Right 70
This safe is located in the ARK Monitor Control Room near the Lobby area. The safe contains a Med Injector, a Bottle of Acid, and an Empty Bottle.