This guide shows the location of all 10 Symbiote Nests in the Spiderman 2 game, which released on 20 October 2023. 5 of the Symbiote Nests are unlocked after you have completed Main Quest 26: Trouble With Harry and the remaining 5 are unlocked after Main Quest 28: Set Things Right.
You need to approach the Nest and plant Sonic Burst on it. At this point, you will be attacked by waves of enemies and a timer will start. Defend the Sonic Burst from the enemies and when the timer ends it will blow up, destroying the Symbiote Nest. Destroying all the 10 Symbiote Nests unlocks the Exterminator trophy.
Area-wise list of Symbiote Nests is shown below
- 2 x Harlem
- 2 x Upper East Side
- 1 x Astoria
- 1 x Upper West Side
- 1 x Chinatown
- 1 x Financial District
- 1 x Williamsburg
- 1 x Little Odessa
Locations of all 10 Symbiote Nests are shown in the pictures below. Symbiote Nests in Harlem, Upper East Side, and Astoria unlock after Main Mission 26 (Marked with yellow squares in the picture below). Symbiote Nests in the Upper West Side, Chinatown, Financial District, Williamsburg, and Little Odessa unlock after Main Mission 28 (Marked with orange squares in the second and third picture below).